Persistent Hyperplastic Primary Vitreous (PHPV) is best described as:

Persistent Hyperplastic Primary Vitreous (PHPV) is best described as:

• A. A congenital anomaly where the primary vitreous fails to regress
• B. A normal vitreous development
• C. An acquired vitreous cyst
• D. A retinal detachment

Answer: (A)

Persistent hyperplastic primary vitreous is a congenital anomaly caused by failure of regression of the primary vitreous and its hyaloid artery during eye development. Normally, this embryonic vascular system nourishes the developing lens and then involutes before birth; when it does not, persistent fetal vasculature remains as fibrovascular tissue behind the lens (retrolental tissue) and can be associated with microphthalmia and leukocoria. This description emphasizes the developmental failure rather than a normal process, an acquired cyst, or a retinal detachment.

Persistent hyperplastic primary vitreous is a congenital anomaly caused by failure of regression of the primary vitreous and its hyaloid artery during eye development. Normally, this embryonic vascular system nourishes the developing lens and then involutes before birth; when it does not, persistent fetal vasculature remains as fibrovascular tissue behind the lens (retrolental tissue) and can be associated with microphthalmia and leukocoria. This description emphasizes the developmental failure rather than a normal process, an acquired cyst, or a retinal detachment.