Which agents should be avoided in secondary glaucoma due to risk of uveitis?

Which agents should be avoided in secondary glaucoma due to risk of uveitis?

• A. Latanoprost, Pilocarpine, Demecarium Bromide
• B. Timolol
• C. Dorzolamide
• D. Acetazolamide

Answer: (A)

When glaucoma is secondary to inflammation, certain eye drops can worsen the inflammatory process. Prostaglandin analogs and older cholinergic agents are avoided because they can elevate intraocular inflammation or disrupt the blood-aqueous barrier. Latanoprost, a prostaglandin analog, can provoke anterior uveitis in susceptible eyes, so it’s avoided in active or inflammatory secondary glaucoma. Pilocarpine, a direct muscarinic agonist, causes miosis and ciliary spasm; this can worsen inflammation and promote synechiae, making it less suitable for eyes with uveitis. Demecarium bromide, an older cholinesterase inhibitor, also increases ciliary effort and has a higher risk of inflammatory reactions, so it’s best avoided in this setting. Other agents like timolol, dorzolamide, and acetazolamide don’t carry the same risk of provoking uveitis and are more commonly used with careful monitoring in inflammatory glaucoma.

When glaucoma is secondary to inflammation, certain eye drops can worsen the inflammatory process. Prostaglandin analogs and older cholinergic agents are avoided because they can elevate intraocular inflammation or disrupt the blood-aqueous barrier.

Latanoprost, a prostaglandin analog, can provoke anterior uveitis in susceptible eyes, so it’s avoided in active or inflammatory secondary glaucoma. Pilocarpine, a direct muscarinic agonist, causes miosis and ciliary spasm; this can worsen inflammation and promote synechiae, making it less suitable for eyes with uveitis. Demecarium bromide, an older cholinesterase inhibitor, also increases ciliary effort and has a higher risk of inflammatory reactions, so it’s best avoided in this setting.

Other agents like timolol, dorzolamide, and acetazolamide don’t carry the same risk of provoking uveitis and are more commonly used with careful monitoring in inflammatory glaucoma.